Evaluation of Frequency of Congenital Hypothyroidism and its Risk Factors in Newborns in Kohgiluyeh County (2013-2016)

Elahe Piraee, Habibollah Azarbakhsh, Zahra Shakolohi, Maysam Abshenas, Mohammad Hossein Ravaee, Sayed Hasan Faghihi

Abstract


Introduction: Congenital hypothyroidism is one of the most common endocrine diseases and is one of the most important causes of mental retardation. The present study was conducted to determine the prevalence of hypothyroidism and its effective factors in Kohgiluyeh County from 2013 to 2016. Materials and Methods: This case-control study was performed on newborns born in Kohgiluyeh County who participated in the congenital hypothyroid screening from March 2013 to February 2016. Neonates with TSH (Thyroid-Stimulating Hormone) were healed more than or equal to 5. Then, their serum TSH level was measured. Newborns with a TSH level greater than or equal to 10 mu / L were considered as congenital hypothyroidism. For each patient, three healthy children were selected as controls. SPSS software was used to analyze the data. Results: The incidence of disease was 5.56 in 1000 live births during these four years, of which 1 case was diagnosed in 180 live births. Boys were 20.6% more likely to have hypothyroidism than girls. There was no significant relationship between the type of delivery and the incidence of hypothyroidism (P> 0.05). Also, there was a significant relationship between the history of hypothyroidism in the family and hypothyroidism (P = 0.001). Conclusion: The prevalence of congenital hypothyroidism in Kohgiluyeh County city is more than national and global statistics, which has concerns (1: 180 live births).


Keywords


Congenital hypothyroidism, screening, neonates

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References


La Franchi S. Congenital hypothyroidism: etiologies, diagnosis, and Management. Thyroid 1999; 9(7): 7357-40.

Buyukgebiz A.Congenital hypothyroidism: clinical aspects and late consequences.Pediatri Endocrinol Rev.2003;1:185-90.

Delange F.Neonatel screening for congenital hypothyroidism:results and perspectives.Horm Res. 1997;48(2):51-61.

Smith L. Updated AAP guidelines on newborn screening and therapy for congenital hypothyroidism. American Family Physician.2007;76(3):439, 3.

Klein RZ,Mitchell ML. Neonatal Screening in: Braverman LE, Utiger RD, editors. Werner and Ingbars The Thyroid: A Fundamental and clinical text. 8th ed. Philadelphia : Lippincott Williams and Wilkins ; 2000.p.973-7.

Brown RS. The thyroid gland. In: book CGD, Hindmarsh PC, editors. Clinical pediatric endocrinology. 4th ed. Oxford: Blackwell Science; 2001.P.228-320.

Moreno JC, Bikker H, Kempers MJ, van Trotsenburg AS, Baas F, de Vijlder JJ, et al. Inactivating mutations in the gene for thyroid oxidase 2 (TH0X2) and congenital hypothyroidism. N Eng j MED. 2002 JUL 11;347(2):95-102.

Tylek –Lemanska D, Ratajczak R, Szczepniak B, Dziatkowiak H, Rybakowa M. Mass screening program for congenital hypothyroidism in south-easterm Poland. J pediatr Endocrinol Metab1999; 12:653-7.

Harris KB, Pass KA.Increase in congenital hypothyroidism in New York State and in the United States. Mol Genet Metab 2007; 91 :268-77.

Ordookhani A, Mirmian P, Hedayati M, Hajipour R, Azizi F. An interim report of the pilot study of screening for congenital hypothyroidism in Tehran and Damavand using cord blood spot samples. Eur J Pediatr. 2003 Mar; 162(3):202-3.

Hashemi Pour M, Taghavi A, Mosayyebi Z, Karimi Dana M, Amini M, Iran Pour R, et al. Screening for congenital hypothyroidism in Kashan, Iran. J Mazand Univ Med Sci 2005; 14(45): 91-83 (Persian).

M. Hashemipour, R. Iranpour, M. Amini, S. Hovsepian, S. Haghighi. Comparision of the Recall Rate Using Two Different Diagnostic Criteria at Isfahan Screening Program for Congenital Hypothyroidism. J Rafsanjan Univ Med Sci 2004; 3(3): 134-140 (Persian).

JVV Antúnez (2016). Hipótesis para un derecho alternativo desde la perspectiva latinoamericana. Opción 32 (13), 7-10.

Delavari AR, Yarahmadi S, Birjandi R, Mahdavi AR, Norouzi Nejad A, Dini M. Cost-benefit analysis of the neonatal screening program implementation for congenitalhypothyroidism in I. R. Iran.Int J Endocrinol Metab.2006;4:84–87.

Hashemi Pour M, Taghavi A, Mosayyebi Z, Karimi Dana M,

Amini M, Iran Pour R,et al.Screening for congenital hypothyroidism in Kashan, Iran. Journal of Mazandaran University of Medical Sciences 2005;14:91-83.

Rastogi MV, LaFranchi SH. Congenital hypothyroidism Orphanet J Rare Dis 2010; 10:17.

Lafranchi S. Disorders of the thyroid gland. In: Behrman RE. Kliegman RM, Schor NF, Stanton BF, eds. Nelson text book of pediatrics. 19thed. Philadelphia: Saunders; 2011. P.1894-900.

Karamizadeh Z, Amirhakimi GH. Incidence of congenital hypothyroidism in Fars Province, Iran. Iran J Med Sci. 1992; 17(1-2): 78-80. [Persian]

Eftekhari N, Asadikaram Gh, Khaksari M, Salari Z, Ebrahimzadeh M. The Prevalence rate of congenital hypothyroidism in Kerman/Iran in 2005-2007. Journal of Kerman University of Medical Sciences. 2008; 15(3): 243-50. [Persian]

S Abisheva, Z Polyak, S Serikova, Z Kermeshova, D Sabirova (2018). Poetics of modern literature of Kazakhstan. Opción, Año 33, No. 85 (2018):344-361.

Zamani N, Mamdoohi Sh, Pashmkar F. The Incidence of congenital hypothyroidism in Boroujerd city. Proceeding of the 3 rdIranian Congress of Pediatric Endocrinology; 2010; Nov 30-Dec 3, Isfahan, Iran.

Talaei M, Ahmadian M, Rezayatmand M. Epidemiol ogical situation of neonatal congenital hypothyroidism screening in 1388 in Isfahan Health Center Number Two. Proceeding of the 3rd Iranian Congress of Pediatric Endocrinology; 2010; Nov 30- Dec 3, Isfahan, Iran.

American academy of pediatrics. Update of newborn screening and therapy for congenital hypothyroidism. Peditrics. 2006; 117 (6):2290-303.

Zeinalzadeh AH, Koush A, Talebi M, Akhtari M.[Screening for congenital hypothyroidism in east Azerbaijan province, IRAN(Persian)]. Journal of Kerman University of Medical Sciences.2011;18(4):301-.8

Medda E,Olivieri A,Stazi MA,Grandolfo ME,Fazzini C,Baserga M,et al.Risk factors for congenital hypothyroidism:results of population case - control study( 1997-2003).Eur J Endocrinol. 2005 Dec;153:765-73.

ISAYEVA E., GABDRAKHMANOV N., RUBTZOV V., The Main Directions of the Dynamics of Labor Resource Potential of the Republic of Tatarstan, Astra Salvensis, Supplement No. 2, 2017, p. 167.

GABDRAKHMANOV N.K., KREIDENKO T.F., ALEKSANDROVNA R.I., MIKHAILOVNA G.E., Problems of Energy Services Market Development in the Regional Economy of the Russian Federation, Astra Salvensis, Supplement No. 2, 2017, p. 203.


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